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  • Early Stage Researcher (ESR/PhD) in the European Training Network “TRANSMIT – TRANSlating the role of Mitochondria in Tumorigenesis” (H2020-MSCA-ITN-2016) - ESR 11 (University Hospital of the Paracelsus Medical University Salzburg, Austria)

    Posted: 
    Monday, 20 March 2017
    Expires: 
    Monday, 15 May 2017

    TRANSMIT - TRANSlating the role of Mitochondria in Tumorigenesis

    The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-todate omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.

     

    ESR11 Impact of ketogenic diet in relation to tumor biology: TRANSMIT is a multi-partner project that intends to mobilise the critical mass of expertise, by linking partners from 10 world-leading basic science and clinical centres of excellence, SMEs with direct interest in mitochondrial cancer metabolism, as well as a non-profit foundation with a 25-year history of advanced training.

    At the Department of Paediatrics at the Paracelsus Medical University in Salzburg - Austria an early stage researcher (ESR) position is available. We are a multi-disciplinary centre of competence whose objective is to offer diagnostic services and research for mitochondrial disorders. Based on our extensive competence in mitochondrial biology we also established a research program on tumor metabolism

     

    Job description: A bulk of evidence has been accumulated in recent years demonstrating that neoplastic development is tightly linked with and dependent on mitochondrial metabolism.  The ESR will directly target the increased glycolysis and low OXPHOS activity of solid cancers by dietary intervention. Due to the metabolic adaptability of cancer cells, it may be necessary to combine agents that target different metabolic pathways to achieve high therapeutic efficacy. Targeting of metabolic reprogramming in cancer cells should render them more sensitive to classical chemo or radiation therapy and would likely permit reduced drug doses or duration of treatment. Different diets in combination with chemotherapeutics will be used to treat mice with xenografts. The effect of the treatments on important parameters of tumour progression will be determined. The studies will reveal if the success of the dietary intervention depends on specific alterations of tumor cell metabolism.

    PhD program in which the ESR will be enrolled: The ESR can enroll for PhD studies in medical sciences (http://www.pmu.ac.at/en/medicalsciencephd.html) at the Paracelsus Medical Universtiy (www.pmu.ac.at). The qualification objectives of the "Ph.D. Scient. Med." correspond to the Level 8 of the European qualification framework for lifelong learning. The knowledge, skills and competences acquired after the successful completion of the doctorate study permit to the graduates to exercise the scientific research as a profession and they are thus in a position to fulfil the specific scientific as well as the professional requirements in this area of activity.

    Alternatively the ESR has the possibility to enroll in the Doctoral program of the Faculty of Natural Sciences of the University Salzburg (www.uni-salzburg.at).

     

    Benefits

    ·         The ESR will be appointed as Marie Sklodowska-Curie Fellow with a 3-year employment contract (38.5 hours per week) at 39100 euro/year, 600 euro/month mobility allowance and family allowance depending on family situation. The net salary results from deducting all compulsory (employer/employee) social security contributions as well as direct taxes (e.g. income tax) from the gross amounts. The rate indicated here is for researchers devoting themselves to their project on a full-time basis.

    ·         A highly multidisciplinary, cross-cultural and competitive training program in the field of metabolism in cancer.

    ·         The appointment is offered in conjunction with an enrollment in a PhD program. PhD tuition fees for the candidate are covered and the research project is aimed at defending a thesis and obtaining a PhD degree.

    ·         In addition to the scientific project, the ESR will benefit from further continuing training, which includes summer schools and secondments, a variety of training courses as well as transferable skill courses, active participation in workshops and conferences, and exposure to SME(s) and universities from the different European countries.

    ·         Vacation days/year: 25 days

    Starting date: Summer/autumn 2017 but never later than January 1st, 2018.

     

    Eligibility criteria

    Required Educational Level: Master, Msc

    Degree Field: The successful candidates must be in possession/just finishing a university Masters degree in chemistry, biology, genetics, molecular biology, biochemistry, pharmacy, medicine, or related fields.

    Skills: A background in cancer metabolism or experience with in vivo models would be an advantage.

    Languages:  As the ESRs will be working in an international and interdisciplinary environment, an excellent command of English (written and oral) is mandatory.  Basic knowledge in German is an advantage

    Status ESR: At the date of recruitment – the ‘early stage researcher’ has to be in the first four years (full time equivalent research experience) of his/her research career and not have been awarded a doctoral degree.

    Trans-national mobility (i.e. move from one country to another) is an essential requirement of MSCA-ITN. The ESR can be of any nationality. At the time of recruitment by the host organisation, he/she must not have resided or carried out his/her main activity (work, studies, etc) in the country of the host organisation for more than 12 months in the three years immediately before the reference date. Compulsory national service and/or short stays such as holidays are not taken into account.

     

    Applications, in English, should include CV, detailed academic transcripts, a copy of the thesis, a motivation letter and a reference letter, which are all to be submitted by email to b.kofler@salk.at

     

    Selection criteria

    First selection step: Curriculum evaluation. Numerical scores will be awarded for grading criteria such as study marks, duration of study, scientific publications in peer reviewed journals, reference letters. Only the admitted candidates will be contacted by e-mail for the second selection step.

    Second selection step: Skype or face-to-face interview in which candidates will give a short presentation of their master thesis and of a scientific paper that they will receive a week before the interview.

     

    The University seeks to increase the number of its female faculty and staff members. Therefore qualified women are strongly encouraged to apply. In case of equal qualification, female candidates will be given preference unless reasons specific to an individual male candidate tilt the balance in his favour.

     

    Deadline for submission: 15th of May 2017, until position is filled

    This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No.: 722605

     

    Applications to:

    a.o.Univ. Prof. Dr. Barbara Kofler

    Research Program for Receptor Biochemistry and Tumor Metabolism

    Department of Pediatrics

    Paracelsus Medical University Salzburg

    Muellner Hauptstr. 48

    A-5020 Salzburg

    Austria

    b.kofler@salk.at

    Qualifications: 
    Required Educational Level: Master, Msc; Degree Field: the successful candidates must be in possession/just finishing a university Masters degree in chemistry, biology, genetics, molecular biology, biochemistry, pharmacy, medicine, or related fields.
    Salary: 
    39100 euro/year, 600 euro/month mobility allowance and family allowance depending on family situation
    Employers: 
    University Hospital of the Paracelsus Medical University Salzburg, Austria
    Job type: 
    Temporary: 3-year employment contract
    Location: 
    Salzburg, Austria
    Contact: 
    Prof. Dr. Barbara Kofler (b.kofler@salk.at)
  • Early Stage Researcher (ESR/PhD) in the Marie Skłodowska-Curie ITN European Training Network “TRANSMIT – TRANSlating the role of Mitochondria in Tumorigenesis” (H2020-MSCA-ITN-2016) - ESR 4 (University of Cambridge, UK)

    Posted: 
    Monday, 20 March 2017
    Expires: 
    Sunday, 30 April 2017

    TRANSMIT - TRANSlating the role of Mitochondria in Tumorigenesis

    The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-todate omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.

     

    ESR (Early Stage Researcher) position for 36 months at Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK

    The Frezza laboratory focuses on understanding the role of the mitochondrial enzyme and component of the tricarboxylic acid (TCA) cycle Fumarate Hydratase in tumorigenesis. We have recently demonstrated that fumarate, accumulated in FH-deficient cells, elicits a powerful epigenetic reprogramming that leads to the suppression of miRNA200, and induction of epithelial–to-mesenchymal transition (Sciacovelli et al, Nature 2016). This epigenetic and phenotypic switch makes FH-deficient cells more motile and invasive, predisposing to metastasis. Although we demonstrated that fumarate has a role as epigenetic modifier, its effects on chromatin structure and function are still unknown. This project will help to elucidate the link between TCA cycle dysfunction, accumulation of fumarate, and downstream epigenetic changes involved in tumorigenesis. To this aim the ESR will investigate the hypothesis that fumarate controls the activity of histone and DNA demethylases involved in DNA and histone methylation, causing broad epigenetic changes. The ESR will first generate a 3D cellular model of FH-deficiency by deleting FH in human renal cell lines obtained using CRISPR technology. He/she will then perform comprehensive subcellular metabolomics analyses to study the metabolic changes induced by the loss of FH in a compartment-specific manner, focusing in particular on the accumulation of fumarate in the nucleus. Then, the ESR will perform an extensive epigenetic analysis aimed at understanding how fumarate modulates genes expression and chromatin structure by altering DNA methylation and histone marks deposition. To assess DNA methylation, genome scale bisulfite sequencing and liquid chromatography analyses will be performed. Further, ESR will also perform Chip-bisulfite sequencing analyses to evaluate changes in histones binding to chromatin and their association to methylated DNA. These epigenetic changes will be merged with RNA-seq experiments to find the link between epigenetic modification and gene expression.

    Subject area of PhD program in which the ESR will be enrolled and PhD program duration: 3-year enrollment to a PhD Medical Science

    Host University that will provide the PhD degree: University of Cambridge 

    PhD program starting date: 01/10/2017 

    Required Educational Level

    Degree: Applicants should hold a Masters level Degree in Biological Sciences in the field of Biochemistry, Cell Biology, or Cancer Biology.

    Skills: The ideal candidate should be familiar with the field of cancer metabolism and have a clear understanding of cellular metabolism and mitochondrial physiology. He/she will have proven experience with cell culture and several lab techniques, including western blotting, molecular biology. The ideal candidate should also be familiar with the basics bioinformatics tools and be familiar with software for data analysis. A distinct advantage will be previous experience with metabolomics experiments and work in the field of caner metabolism, and familiarity with epigenetics.

    Additional requirements: Team spirit, good communication skills, and trans-national mobility

    Languages: English

     

    Eligibility: The applicants must be in possession of a degree in Biological sciences at the date of recruitment

    - an ‘early stage researcher’ (i.e. in the first four years of his/her research career and not have a doctoral degree). The applicants must not have resided in the country where the research training activities take place for more than 12 months in the 3 years immediately prior to the recruitment date and not have carried out their main activity (work, studies, etc.) in that country. 

    The applicant may be a national of a Member State, of an Associated Country or of any other Third Country.

     

    Benefits

    •         Enrollment in a PhD school in Medical Science 

    •         3-year employment contract and a salary of 44,895 Euro per annum augmented by a mobility allowance of 7,200 Euro per annum

    •         A highly multidisciplinary, cross-cultural and competitive training program in the field of metabolism in cancer 

    •         Secondments and a specific training program 

    •         Vacation days/year: 33 days + bank holidays

     

    Selection criteria

    Applications, in English, should include a CV, a covering letter, detailed academic transcripts, a copy of the master’s thesis and a letter of reference - all to be submitted by email to Christine Fox (cf208@MRCCU.cam.ac.uk). Application deadline: 30 April 2017.

    First selection step: Curriculum evaluation. Numerical scores will be awarded for various grading criteria such as study marks obtained, duration of study, scientific publications in peer reviewed journals, reference letter. Only those candidates who are shortlisted from this step will be contacted by e-mail for the second selection step.

    Second selection step: Skype or face-to-face interviews in which candidates will be required to give a short presentation of their master’s thesis and to discuss a scientific paper that they will receive before the interview. The interview panel will include the principal investigator and other members of the host laboratory.  

    Qualifications: 
    Masters level Degree in Biological Sciences in the field of Biochemistry, Cell Biology, or Cancer Biology.
    Salary: 
    44,895 Euro per annum augmented by a mobility allowance of 7,200 Euro per annum
    Employers: 
    University of Cambridge, UK
    Job type: 
    Temporary: 3-year employment contract
    Location: 
    Cambridge, UK
    Contact: 
    Christine Fox (cf208@MRCCU.cam.ac.uk).
  • Early Stage Researcher (ESR/PhD) in the Marie Skłodowska-Curie ITN European Training Network “TRANSMIT – TRANSlating the role of Mitochondria in Tumorigenesis” (H2020-MSCA-ITN-2016) - ESR 3 (Justus Liebig University of Giessen, Germany)

    Posted: 
    Monday, 20 March 2017
    Expires: 
    Monday, 1 May 2017

    TRANSMIT - TRANSlating the role of Mitochondria in Tumorigenesis

    The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-todate omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.

     

    Project Description

    1) Job Summary: ESR (Early Stage Researcher) position for 36 month at the Institute of Veterinary Physiology and Biochemistry, Justus-Liebig-University of Giessen, Germany

    2) Job description: Application refers to an Early Stage Researcher (ESR) position available in the H2020 Marie Skłodovska Curie Innovative Training Networks to be trained at the Department of Veterinary Physiology and Biochemistry, University of Giessen, Germany

    Cancer cell proliferation strongly depends on the availability of energy and metabolic precursors for the synthesis of cell building blocks which implies a close coordination between the associated key pathways glycolysis and glutaminolysis. The ESR will investigate the effect of different nutrient deficiency protocols as well as inhibitors of selected cytosolic and mitochondrial enzymes on the composition of the glycolytic enzyme complex as well as the coordination of the glycolytic and glutaminolytic conversion rates in tumor cell lines with different metabolic characteristics. In selected cell models with most effective treatment protocols the metabolic fate of glucose and glutamine will be determined using mass spectrometry.

    3) Subject area of PhD program in which the ESR will be enrolled and PhD program duration: PhD programme of the Faculties of Veterinary Medicine and Medicine; Section Metabolism; Duration 3 years

    4) Host University that will provide the PhD degree: Justus Liebig University of Giessen, Germany

    5) PhD program starting date: October 1st, 2017

    Required Educational Level

    Degree: Master Degree in Biology, Biochemistry, Biotechnology, Nutritional Sciences, Chemistry or Completed University Degree in Veterinary Medicine or Medicine

    Degree Field: Biochemistry, Cellular and Molecular Biology, Molecular Genetics

    Skills: highly motivated, team player, self-organized, goal orientated working style. Experience in a research lab, proficiency in basic techniques in Biochemistry and / or Cell Biology, i.e. cell culture, ectrophotometry, western blotting, PCR are of benefit.

    Languages: Fluent written and spoken English is mandatory. Basic knowledge in German is an advantage.

     

    Applications, in English, should include CV, detailed academic transcripts, a copy of the master thesis, a motivation letter and at least one reference letter from a former supervisor or lecturer, which are all to be submitted until May 1st, 2017 by Email to Prof. Dr. Sybille Mazurek (Email: Sybille.Mazurek@vetmed.uni-giessen.de).

     

    Elegibility: The applicants must be in possession of a degree in Biochemistry, Biology, Biotechnology, Nutritional Sciences, Chemistry, Veterinary Medicine or Human Medicine at the date of recruitment - an ‘early stage researcher’ (i.e. in the first four years of his/her research career and not have a doctoral degree).

     

    The applicant may be a national of a Member State, of an Associated Country or of any other Third Country.

    The applicants not have resided in the country where the research training activities take place for more than 12 months in the 3 years immediately prior to the recruitment date and not have carried out their main activity (work, studies, etc.) in that country.

     

    Benefits

    ·         Enrollment in a PhD school in a specific area

    ·         3-year employment contract (total gross amount for three years: 110.616,48 Euro living cost plus 21.600,00 Euro mobility allowance plus familiar allowance depending upon the familiar status of the applicant at the time point of recruitment.

    ·         A highly multidisciplinary, cross-cultural and competitive training program in the field of metabolism in cancer (or molecular oncology)

    ·         Secondments and a specific training program

    ·         Vacation days/year: 30 days

     

    Selection criteria

    First selection step: Curriculum evaluation. Numerical scores will be awarded for grading criteria such as study marks, duration of study, scientific publications in peer reviewed journals, reference letters. Only the admitted candidates will be contacted by e-mail for the second selection step.

    Second selection step: Skype, phone or face-to-face interview in which candidates will give a short presentation of their master thesis and of a scientific paper that they will receive two to three weeks before the interview.

     

    The University seeks to increase the number of its female faculty and staff members. Therefore qualified women are strongly encouraged to apply.

     

    Evaluation period: 4 weeks 

    Qualifications: 
    Degree: Master Degree in Biology, Biochemistry, Biotechnology, Nutritional Sciences, Chemistry or Completed University Degree in Veterinary Medicine or Medicine; Degree Field: Biochemistry, Cellular and Molecular Biology, Molecular Genetics
    Salary: 
    Total gross amount for three years: 110.616,48 Euro living cost plus 21.600,00 Euro mobility allowance plus familiar allowance depending upon the familiar status of the applicant at the time point of recruitment).
    Employers: 
    Justus Liebig University of Giessen, Germany
    Job type: 
    Temporary: 3-year employment contract
    Location: 
    Giessen, Germany
    Contact: 
    Prof. Dr. Sybille Mazurek (Sybille.Mazurek@vetmed.uni-giessen.de)
  • Early Stage Researcher (ESR/PhD) in the Marie Skłodowska-Curie ITN European Training Network “TRANSMIT – TRANSlating the role of Mitochondria in Tumorigenesis” (H2020-MSCA-ITN-2016) - ESR 2 (OROBOROS INSTRUMENTS GmbH, Austria)

    Posted: 
    Monday, 20 March 2017
    Expires: 
    Monday, 15 May 2017

    TRANSMIT - TRANSlating the role of Mitochondria in Tumorigenesis

    The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-to-date omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.

     

    Project Description

    1)  Job summary

    The researcher will be involved in the development, evaluation and application of new respiratory substrate-uncoupler-inhibitor-titration (SUIT) protocols designed to assess the role of mitochondrial NAD-linked malic enzyme in mitochondrial and cellular energetics of cancerous and benign cells. In addition, ERS2 will help improving the extension of high-resolution respirometry to MultiSensor analysis enabling the simultaneously measurement of several mitochondrial functions (e.g. mitochondrial membrane potential and reactive oxygen species levels and proton production rates as an estimate of glycolytic activity). These measurements will contribute to the identification of mitochondrial metabolic biomarkers for characterizing the transformation from benign to cancer cells and this will subsequently be extended using proteomics and metabolite tracing.

    2) Job description

    Cell ergometry and mitochondrial metabolic biomarkers in cancer

    After a brief period of re-emergence of the Warburg effect in oncological research, the underlying concept has been shown to be ineffective for elucidating causal relationships between mitochondrial dysfunction and tumor progression. During metabolic re-programming in many cancers and actively dividing cells mitochondrial respiratory competence is retained with a shift towards biosynthetic functions (Tan AS et al. Cell Metab 21:81-94, 2015). Mitochondrial NADH-linked malic enzyme (ME2) does not only play a key role in glutaminolysis, but its enforced expression suppresses senescence, whereas downregulation of ME2 modulates the outcome of p53 activation, leading to strong induction of senescence but not apoptosis (Jiang P, et al. Nature 493:689-93, 2013). Development, evaluation and application of new respiratory substrate-uncoupler-inhibitor-titration (SUIT) protocols are required to assess the role of ME2, which is allosterically controlled by fumarate, succinate and ATP, in mitochondrial respiratory control in cancer versus benign cells. SUIT protocols are a hallmark of the success of high-resolution respirometry and cell ergometry (Gnaiger E. 4th ed. Mitochondr Physiol Network 19.12, 2014;  Pesta, D, Gnaiger E. Methods Mol Biol, 810:25-58, 2012). ESR2 will improve the extension of high-resolution respirometry to MultiSensor analysis for simultaneous evaluation of several mitochondrial functions (e.g. mitochondrial membrane potential, reactive oxygen species production, proton flux in comparison to aerobic lactate production). This approach will contribute to the identification of mitochondrial metabolic biomarkers for characterizing the transformation from benign to cancer cells. ESR2 will therefore develop and test such novel biomarker protocols initially on prostate cancer cells, in comparison with metabolic remodeling of non-cancer epithelial cells. One secondment will extend the study with proteomics and metabolite tracing. Another secondment will aim at a detailed analysis of the respiratory complexes in prostate cancer cells versus non-cancer epithelial cells.

    3) Host University that will provide the PhD degree:

         Medical University of Innsbruck, www.i-med.ac.at

    4) Subject area of PhD program in which the ESR will be enrolled over the three-year PhD program duration: Molecular Cell Biology / Molecular Oncology

    5) PhD program starting date

         2017-10-01

    Required Educational Level

    Degree: Master of Science

    Degree field: Natural Sciences

    Skills: team-player, self-organized, goal-oriented working style,

    Languages: English, additional languages, e.g. German, of benefit

    (Applicant should be fluent in written and spoken English)

     

    Applications, in English, should include CV, detailed academic transcripts, a copy of the thesis, a motivation letter and a reference letter, which are all to be submitted by email to verena.laner@oroboros.at

     

    *Eligibility: The applicants must be in possession of a Master’s degree at the date of recruitment - an ‘early stage researcher’ (i.e. in the first four years of his/her research career and not have a doctoral degree).

     

    The applicant may be a national of a Member State, of an Associated Country or of any other Third Country. The applicants must not have resided in the country where the research training activities take place for more than 12 months in the 3 years immediately prior to the recruitment date and not have carried out their main activity (work, studies, etc.) in that country.

     

    Benefits

    ·         Enrollment in a PhD school in a specific area

    ·         3-year employment contract (2.534 EUR gross/month, 14x per year incl. mobility allowance)

    ·         A highly multidisciplinary, cross-cultural and competitive training program in the field of metabolism in cancer (or molecular oncology)

    ·         Secondments and a specific training program

    ·         Vacation days/year: 25

     

    Selection criteria

    First selection step: Curriculum evaluation. Numerical scores will be awarded for grading criteria such as study marks, duration of study, scientific publications in peer reviewed journals, presentations at conferences, participation in training workshops, reference letters. Only the admitted candidates will be contacted by e-mail for the second selection step.

    Second selection step: Skype or face-to-face interview in which candidates will give a short presentation of their master thesis and of a scientific paper that they will receive two to three weeks before the interview.

     

    Deadline for application:      15. May 2017

    Evaluation period:                 45 days

    Website:                                 wiki.oroboros.at/index.php/TRANSMIT

    Qualifications: 
    Degree: Master of Science; Degree field: Natural Sciences
    Salary: 
    2.534 EUR gross/month, 14x per year incl. mobility allowance
    Employers: 
    OROBOROS INSTRUMENTS GmbH
    Job type: 
    Temporary: 3-year employment contract
    Location: 
    Innsbruck, Austria
    Contact: 
    Verena Laner (verena.laner@oroboros.at)
  • Surviving metabolism: acid handling and signalling in cancer

    Posted: 
    Friday, 24 February 2017
    Expires: 
    Friday, 24 March 2017

    TWO Fixed term posts on Grade 7

    For five years, starting June 1st

    Click here for more information

    Closing date: 24th March 2017

     

    To apply, search "surviving" on ox.ac.uk/jobs

    Qualifications: 
    PostDoc
    Salary: 
    £ 31,076 to £38,183 p.a.
    Employers: 
    Pawel Swietach - University of Oxford
    Job type: 
    Postdoctoral Research Scientists
  • 2 postdoctoral positions in Prague, Czech Republic

    Posted: 
    Thursday, 12 January 2017
    Expires: 
    Tuesday, 28 February 2017

    Department of bioenergetics, Institute of Physiology CAS is looking for 2 highly motivated postdoctoral fellows with Ph.D. or equivalent degree to work on GA CR (Czech Science Foundation) funded projects. The contracts are fixed till December 31, 2018 but with potential for prolongation from other sources. You will get the opportunity to become a member of our young and dynamic team based in state of the art facilities within the biomedical campus of the Czech Academy of Sciences located at the outskirts of Prague. For details about the department, you can check our webpage:  http://fgu.cas.cz/en/departments/bioenergetics. Applications will be accepted until the position is filled.

    Position 1: Characterisation of the role of DAPIT protein in the biogenesis of mammalian mitochondrial ATP synthase (PI and the head of department: Tomas Mracek)

     

    Recently, we have developed rat knockout model for DAPIT subunit with not yet known function in this enzyme complex. This project will focus on characterisation of enzyme biogenesis and biochemical function in control versus knockout animals. Other branch will focus on whole body phenotyping of metabolic functions in knockout animals to establish organ specificity and develop our understanding how compromised mitochondrial energy provision can influence/dictate metabolic phenotypes.

    Position 2: Mitochondrial glycerol-3-phosphate dehydrogenase as a target for anti-tumour therapies (PI: Alena Pecinova)

    Mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mGPDH) is inducible and highly tissue/cell specific enzyme typically active in glycolytic cells.  Main aim of this project is to verify mGPDH as a potential druggable target in tumour cells and confidently identify those cancer cell lines which are negatively affected by traditional and novel mGPDH inhibitors. Project will include work on tumour cell lines, biochemical characterisation of inhibitors’ mode of action and data mining for tumour types, which are dependent on mGPDH.

    Applicants should fulfil following criteria:

    • Have completed the PhD before start of the contract.
    • Have a strong track record in one or more of the following areas: biochemistry, cell biology, molecular biology, or animal physiology. Experience with –omics data analysis is also welcome.
    •  Be fluent in English.

    The applications should be sent to tomas.mracek@fgu.cas.cz and contain:

    • Curriculum Vitae.
    • List of publications / summary of previous research experience
    • Recommendation letters or (preferably) e-mail contacts to two referees – at most one from the applicant’s current affiliation.
    Qualifications: 
    Phd in biochemistry, cell biology or similar
    Salary: 
    500,000 CZK / year
    Employers: 
    Institute of Physiology of the Czech Academy of Sciences
    Job type: 
    Postdoc
    Location: 
    Prague, Czech Republic
    Contact: 
    tomas.mracek@fgu.cas.cz
  • Several granted positions in Prof. Sonveaux's lab, Brussels, Belgium

    Posted: 
    Wednesday, 2 March 2016
    Expires: 
    Thursday, 31 March 2016

    The following positions are currently available at the Pole of Pharmacology & Therapeutics of the University of Louvain (UCL) Medical School in Brussels, Belgium. https://www.uclouvain.be/fath.html

     

    Position 1: A salary of minimum 1 year (+ 1 year possible renewal) for a Research Assistant in the field of Preclinical Cancer Research in the team of Prof. Pierre Sonveaux. The Research Assistant will be in charge of the scientific administration of a laboratory active in the field of Tumor Metabolism. He/she will be in charge of scouting for grant opportunities, editing the scientific content of grant applications and scientific papers, maintaining the website of the laboratory and providing scientific support to the PI, postdocs and PhD students of the lab. The applicant should be graduated in Biomedical Sciences, Pharmacy, Biology or a related field. He/she must be fluent both in English and in French. To apply, refer to ASSISTANT1.

     

    Position 2: A Postdoctoral grant of minimum 1 year (+ 1 year possible renewal) in the field of Preclinical Cancer Research in the team of Prof. Pierre Sonveaux. The Postdoc will perform a study in which a new compound, Compound A, will be tested in vivo in small laboratory animals. He/She will be in charge of establishing the Pharmacokinetics, Pharmacodynamics and efficacy of the compound used as a single agent in various types of metastatic cancer models. Experience in Preclinical Cancer Therapy (oral, i.v. and i.p. drug delivery, blood and body fluid sampling), small animal surgery, a legal certificate (from any country) for the use of small laboratory animals and fluency in English are required. At least one publication in international journals with impact factor ≥ 4 is mandatory. To apply, refer to POSTDOC1.

     

    Position 3: A Postdoctoral grant of minimum 1 year (+ 1 year possible renewal) in the field of Preclinical Cancer Research in the team of Prof. Pierre Sonveaux. The Postdoc will perform a study in which a new compound, Compound B, will be tested in vivo in small laboratory animals. He/She will be in charge of establishing the Pharmacokinetics, Pharmacodynamics and efficacy of the compound used as a single agent in various types of metastatic cancer models. Experience in Preclinical Cancer Therapy (oral, i.v. and i.p. drug delivery, blood and body fluid sampling), small animal surgery, a legal certificate (from any country) for the use of small laboratory animals and fluency in English are required. At least one publication in international journals with impact factor ≥ 4 is mandatory. To apply, refer to POSTDOC2.

     

    Position 4: A Postdoctoral grant of minimum 1 year (+ 1 year possible renewal) in the field of Preclinical Cancer Research in the team of Prof. Pierre Sonveaux. The Postdoc will perform a study in which a new compound, Compound B, will be tested in vivo in small laboratory animals. He/She will be in charge of demonstrating that Compound B does not interfere with chemo- and radiotherapy in various types of metastatic cancer models. Experience in Preclinical Cancer Therapy (oral, i.v. and i.p. drug delivery, blood and body fluid sampling), small animal surgery, a legal certificate (from any country) for the use of small laboratory animals and fluency in English are required. At least one publication in international journals with impact factor ≥ 4 is mandatory. To apply, refer to POSTDOC3.

     

    Positions 5: A salary of minimum 1 year (+ 1 year possible renewal) for a Laboratory technician in the field of Preclinical Cancer Research in the team of Prof. Pierre Sonveaux. The technicians should demonstrate motivation, team work ability and proactivity, as well as experience in cell culture and in vitro experiments. Sufficient English skills to work in an international team are required. Motivation will take precedence over expertise. On site formation will be provided in Genetics, Molecular and Cell Biology, Oncology and in vivo experiments.

     

    There will be no overlap between the different postdoctoral projects.

    Application deadline is March 31st, 2016. Earliest possible start date is April 15th  2016. Applicants should submit a single PDF file containing a statement of research interests, a detailed curriculum vitae, a scan of their PhD diploma, a scan of their certificate regarding the use of small laboratory animals if required, and names of at least 2 Senior Referees to secretaire-fath@uclouvain.be.

    Qualifications: 
    see offer
    Salary: 
    Grant
    Employers: 
    Prof. Pierre Sonveaux (UCL)
    Job type: 
    1 Assistant, 3 Postdocs, 1 Tech
    Location: 
    Brussels
    Contact: 
    secretaire-fath@uclouvain.be
    Qualifications: 
    see offer
  • Postdoctoral position - Cancer Metabolism - NTNU, Trondheim, Norway

    Posted: 
    Monday, 7 December 2015
    Expires: 
    Thursday, 31 December 2015

    POSTDOC in CANCER METABOLISM

    A position as postdoctoral research fellow at the Dept. of Circulation and Medical Imaging, Faculty of Medicine, NTNU is now open. The postdoc will be part of the MR Cancer Group, a multidisciplinary group dedicated to research on how MR technology can improve diagnosis and therapy in cancer.

    For more information about the research group; www.ntnu.edu/isb/mr-cancer

    The period of employment is two years, with the objective of qualifying for higher academic positions.

     

    PROJECT DESCRIPTION

    The main goal of the project "Cancer metabolism: From basic biochemistry to clinical opportunities" is to increase our understanding of how abnormal metabolism supports the growth of cancer cells and how novel drugs targeting metabolic reactions can be used to treat cancer. The postdoc will work both in vitro and  in vivo, studying metabolic plasticity in response to treatment with targeted drugs. Furthermore, the postdoc will contribute to studies of the association between metabolism and metastasis. If successful, the project will provide new basic knowledge on cancer metabolism, technological innovation in the form of preclinical proof-of-concept and new diagnostic tools based on abnormal metabolic features of cancer cells.

    QUALIFICATIONS

    We seek a talented, enthusiastic and creative scientist with

    - A PhD in Medicine or Molecular Biology (or similar)

    - A strong academic track record

    - Proficiency in oral and written English

    - Practical and theoretical experience with NMR spectroscopy and/or MR imaging

    - Documented hands-on experience with cancer cell culture as well as preclinical disease models.

     

    To apply for the position: www.jobbnorge.no/ledige-stillinger/stilling/119942/position-as-research-...

    For more information: contact Assoc. Prof. Siver Moestue (siver.a.moestue@ntnu.no)

    Qualifications: 
    PhD in Medicine, Molecular Biology or similar
    Salary: 
    NOK 483.400 - 509.800
    Employers: 
    MR Cancer Group, NTNU
    Job type: 
    Postdoctoral Research Fellow
    Location: 
    Trondheim, Norway
    Contact: 
    Assoc. Prof. Siver Moestue (siver.a.moestue@ntnu.no)
  • 3 granted post-doc positions in Cancer Research are now opened

    Posted: 
    Tuesday, 1 September 2015
    Expires: 
    Thursday, 15 October 2015

    3 Granted Postdoc Positions in Cancer Research are available in the lab of Prof. Pierre Sonveaux at the University of Louvain (UCL) Medical School in Brussels, Belgium. The lab has strong expertise in translational Cancer Research (http://www.uclouvain.be/420397.html).

    Postdoc 1:  A grant for a 1-year postdoc position to conduct a project in the field of cancer metabolism and autophagy. The Postdoc will perform a study aimed at developing new anticancer approaches, involving molecular biology, cellular biology and in vivo studies. Experience in molecular biology, biochemistry, cell biology as well as fluency in English are required. At least one publication in international journals with impact factor ≥ 2 is mandatory. To apply, refer to POSTDOC1.

    Postocs 2 and 3: Two grants for 1-year postdoc positions to conduct preclinical research in mice, in order to validate a new anticancer treatment and its biomarkers in collaboration with Clinics and Industry. Experience in the care and use of murine mouse models of cancer is mandatory (monitoring tumor growth and metastasis, administering treatments by gavage, ip, iv). Experience in immunohistochemistry, biochemistry, cell biology as well as fluency in English are required. At least one publication in international journals with impact factor ≥ 2 is mandatory. To apply, refer to POSTDOC2&3.

    Application deadline is October 15th, 2015. Earliest possible start date is October 1st, 2015. Applicants should submit a detailed curriculum vitae, a statement of research interests, a scan of their PhD diploma and names of at least 2 Senior Referees to pierre.sonveaux@uclouvain.be.

    Qualifications: 
    PhD in any domain of Life Sciences
    Salary: 
    good
    Employers: 
    Prof. Pierre Sonveaux, Université catholique de Louvain (UCL)
    Job type: 
    Postdoc
    Location: 
    Brussels
    Contact: 
    pierre.sonveaux@uclouvain.be
  • Postoctoral position in the metabolic phenotype of tumor cells in defined conditions of the microenvironment – in the context of 13C- magnetic resonance spectroscopy

    Posted: 
    Saturday, 30 May 2015
    Expires: 
    Monday, 22 June 2015

    Project description: The altered metabolism of tumors can be monitored with nuclear magnetic resonance (NMR) spectroscopy using NMR-active metabolites. With the implementation of hyperpolarized 13C-molecules such as 13C–pyruvate, it has become possible to measure the metabolic dynamics within a few seconds. The evaluation of the NMR-signals requires knowledge on the influence of the tumor microenvironment on the cellular uptake of metabolites, especially on how nutrient and oxygen deprivation as well as an acidic pH modulate the cellular uptake of 13C-pyruvate. For this, 3D in-vitro tumor cell structures (spheroids) maintained in various tumor-like growth conditions serve as model systems. Further biochemical investigations will focus on 1) the cellular uptake of 14C-pyruvate, 2) the activity of metabolic enzymes, and 3) the metabolic flux of 13C-pyruvate using mass spectroscopy (isotopologue profiling). This project will be done in close cooperation with the Department of Biochemistry and the Clinic for Nuclear Medicine (Klinikum rechts der Isar) at the TUM.

     

    Requirements: The candidate will have a doctoral degree (PhD), a track record of a sound theoretical and practical background in biochemistry and cell biology, preferably in oncology. Experience in working with cells and biochemical assays as required above would be a major advantage. He/she should be dedicated, creative, and diligent in performing sophisticated experiments, and have good skills in communicating concepts and results in good English, including writing publications.
    The postdoctoral position is funded for two years. 
    Please see the website (http://www.imetum.tum.de/about-the-institute/?L=1) for a description of the institute and address any further queries to otto@tum.de.
    The application, including a cover letter, full CV, a brief description of scientific achievements and interests (publications, meetings, awards, etc.), and contact information of 2-3 referees, should be sent to Dr. Angela Otto (otto@tum.de).

     

    Qualifications: 
    PhD
    Salary: 
    The salary will be according to the university tariff (TV-L).
    Employers: 
    Angela Otto
    Job type: 
    PostDoctoral position of two years
    Location: 
    Zentralinstitut für Medizintechnik, Technische Universität München
    Contact: 
    otto@tum.de Tel +49 89 289-10806 Fax +49 89 289-10805

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